LNP 混合芯片
玻璃人字形（herringbone）微流控混合芯片，用于配制 40–200 nm、PDI < 0.2 的脂质纳米颗粒。
| Mixer type | Herringbone, passive |
|---|---|
| Application | Lipid nanoparticle (LNP) formulation |
| Particle size | 40–200 nm |
| Polydispersity (PDI) | < 0.2 |
| Material | Borosilicate glass, transparent |
| Inlets | 2 |
| Channel width | 100–500 µm |
| Channel depth | 80–110 µm |
| Flow rate (water, 3 bar) | up to 3.4 ml/min |
| Max pressure | 15 bar |
| Chip format | 75 × 25 × 2 mm, consumable |
The LNP mixer is a replaceable glass mixer chip for controlled lipid nanoparticle formulation. Its herringbone channel structure generates secondary flows and mixes the lipid and aqueous phases rapidly through flow splitting and recombination rather than slow diffusion. Two inlets bring the phases into the mixing channel; the geometry yields a reproducible particle size of 40–200 nm at PDI < 0.2.
The chip is made of borosilicate glass, chemically resistant to alcohols and the solvents typical of LNP work, and fully transparent for visual flow inspection. Its small internal volume (around 3 µl) minimizes the loss of costly components on start-up.
The chip works as a consumable for the microfluidic platform: every run uses a fresh chip, which eliminates cross-contamination between formulations and removes the need to validate cleaning.
