Micro-HPLC and Micro-GC Chromatographs

Developing and scaling up a synthesis requires quickly determining product composition, residual reagents and by-products in the liquid and gas phase. Conventional HPLC consumes a lot of eluent and sample, periodic gas sampling misses transient regimes, and separate instruments integrate poorly with the reactor — samples are carried by hand and results have to be matched by time.

The platform consists of independent micro-HPLC and micro-GC modules used separately or together within a synthesis line. In the liquid channel, a micropump, low-dispersion injector and microfluidic microbore column reduce eluent use and handle microliter samples, with isocratic and gradient elution. In the gas channel, a micro-injector, short micro-columns and a compact detector give a short analysis cycle for gases and volatiles.

An automatic valve or bypass line takes samples at set intervals without stopping the process, and chromatograms are linked to flow rates, temperature, pressure, fraction number and residence time. Column type, eluent or carrier gas, temperature program and detector set are chosen for the target compounds.

Customers can start with one analytical channel and later add the second chromatography type, a detector, an autosampler or a mass-spectrometer interface. LABADVANCE provides design, method development, commissioning, training and service.