Microfluidic High-Purity Synthesis System
Controlled flow synthesis of small batches on glass chips: precise reaction time, minimal reagent use and reproducible recipes.
| Reactor | replaceable borosilicate glass chip |
|---|---|
| Feeds | precision syringe pumps |
| Temperature control | liquid bath, heated holder or heating/cooling module |
| Processes | single- and multiphase, multistep; gas–liquid in special version |
| Wetted materials | glass, stainless steel, PEEK, PTFE |
| Control | software: recipe, flows, temperature, pressure, log |
| Options | BPR, gas inlet, autosampler, fraction collector, online analytics, safety enclosure |
| Scope of supply | pumps, chips, thermostat, plumbing, control unit, software, installation, training |
Developing high-purity substances often means producing a small series of samples from expensive or scarce components. At small volume a flask is hard to control: local overheating and uneven mixing create by-products, material is lost on walls and during washing, and results depend on the operator.
The LABADVANCE system moves the reaction into a glass microfluidic chip with defined channel geometry and small internal volume. Each reagent is fed by its own precision syringe pump, so stoichiometry is set by flow rates and changed in software; the channel geometry provides reproducible mixing, while reactor volume and total flow define reaction time. The chip is temperature-controlled in a holder or liquid bath, and borosilicate glass lets you see mixing, bubbles, precipitate and phase changes.
The software steps through flow rates, temperature, pressure and residence time, logs all parameters and builds reproducible recipes. Single- and multiphase, sequential and multistep reactions are supported, as are gas–liquid reactions in a special version. The outlet stream goes to a fraction collector or online analytics to assess conversion, purity and yield.
The number of feeds, chip geometry, temperature module and flow-path materials are chosen for the specific reaction; LABADVANCE supplies the pumps, temperature control, fluidics, automation and start-up method. In one internal polymerization process, the microfluidic setup reached full monomer conversion versus 99% in the batch control.